This report assesses the techno-economic feasibility and market uptake potential of zero-emission trucks for four different vehicle segments for the European Union (EU) and the United Kingdom (UK). From a market perspective, switching from ICEVs to ZEVs is considered feasible if parity in the total cost of ownership (TCO) with diesel equivalents is reached and operational limitations such as range constraints, time or payload losses can be avoided. Based on the expected affordability and applicability, the analysis forecasts the ZEV uptake potential for each vehicle segment until the year 2040. A subsequent analysis also examines an accelerated market uptake scenario where policy measures such as vehicle purchase subsidies, CO2-based road tolls and CO2 pricing of transport fuels are taken into account.